Rodŕıguez, “Treatment of infectious mastitis during lactation: antibiotics versus oral administration of lactobacilli isolated from breast milk

Background. Mastitis is a common infectious disease during lactation, and the main etiological agents are staphylococci, streptococci, and/or corynebacteria. The efficacy of oral administration of Lactobacillus fermentum CECT5716 or Lactobacillus salivarius CECT5713, two lactobacilli strains isolated from breast milk, to treat lactational mastitis was evaluated and was compared with the efficacy of antibiotic therapy. Methods. In this study, 352 women with infectious mastitis were randomly assigned to 3 groups. Women in groups A ( ) and B ( ) ingested daily 9 log10 colony-forming units (CFU) of L. fermentum CECT5716np 124 np 127 or L. salivarius CECT5713, respectively, for 3 weeks, whereas those in group C ( ) received the antibioticnp 101 therapy prescribed in their respective primary care centers. Results. On day 0, the mean bacterial counts in milk samples of the 3 groups were similar (4.35–4.47 log10 CFU/mL), and lactobacilli could not be detected. On day 21, the mean bacterial counts in the probiotic groups (2.61 and 2.33 log10 CFU/mL) were lower than that of the control group (3.28 log10 CFU/mL). L. fermentum CECT5716 and L. salivarius CECT5713 were isolated from the milk samples of women in the probiotic groups A and B, respectively. Women assigned to the probiotic groups improved more and had lower recurrence of mastitis than those assigned to the antibiotic group. Conclusions. The use of L. fermentum CECT5716 or L. salivarius CECT5713 appears to be an efficient alternativ